Amphotericin B 1397-89-3 Tshuaj tua kab mob
Kev Them Nyiaj:T / T, L / C
Khoom Keeb Kwm:Tuam Tshoj
Shipping Chaw nres nkoj:Beijing / Shanghai / Hangzhou
Muaj peev xwm ntau lawm:100kg / hli
Order (MOQ):25kg ua
Lub Sijhawm Lead:3 Hnub Ua Haujlwm
Kev cia khoom:nrog lub hnab dej khov rau kev thauj mus los.Khaws ntawm 2-8 ℃ rau lub sijhawm ntev.
Cov khoom siv pob:nruas
Pob loj:25kg / nruas
Cov ntaub ntawv kev nyab xeeb:Tsis yog khoom txaus ntshai
Taw qhia
Amphotericin B, tuaj yeem hu ua Fungizone lossis Ambisome, uas yog cov tshuaj tua kab mob polyene antifungal cais tawm ntawm kab lis kev cai nruab nrab ntawm Streptomycesnodosus.Nws cais los ntawm ob feem nrog A thiab B, tab sis A ib feem yog tsawg dua rau cov tshuaj tua kab mob uas tsis siv, yog li cov neeg siv B feem tsuas yog hu ua Amphotericin B.
Nws yog ib qho tshuaj tua kab mob siv rau cov kab mob fungal thiab leishmaniasis.Nws muaj ob qhov sib txawv siv los ntawm qhov ncauj thiab txhaj tshuaj.
Amphotericin B yog thawj qhov kev xaiv rau kev sib sib zog nqus ntawm cov kab mob fungal vim tias nws muaj ntau yam tshuaj tua kab mob.Nws muaj inhibit functions rau fungals xws li cryptococcus, coccidium, candida albicans thiab blastomycetes, thiab lwm yam yuav tua fugal ntawm siab concentration, uas yog ib tug zoo tshuaj rau kev kho mob ntawm sib sib zog nqus fungal kab mob.
Cov kev kho mob tseem ceeb xws li: 1. Kev kho cov kab mob fungal xws li cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidiosis thiab histoplasmosis.2. Kev kho mob ntawm mucormycosis tshwm sim los ntawm qee cov kab mob xws li Rhizopus, colporium, endomycetes thiab Qav fecal pwm.3. Kev kho mob sporotrichosis tshwm sim los ntawm sporotrichosis schenckii.4. Kev kho mob aspergillosis tshwm sim los ntawm Aspergillus fumigatus.5. Cov tshuaj pleev xim yog tsim rau pigmented mycosis.Nws kuj tseem tsim nyog rau cov kab mob ntawm daim tawv nqaij tom qab kub hnyiab, kab mob ua pa Candida thiab Aspergillus lossis cryptococcus kab mob, nrog rau kev ua haujlwm rau fungal corneal ulcer.
Cov kev mob tshwm sim ib txwm muaj xws li ua npaws, ua daus no, thiab mob taub hau sai tom qab muab tshuaj, nrog rau teeb meem raum.Cov tsos mob ua xua xws li anaphylaxis tuaj yeem tshwm sim.Lwm cov kev mob tshwm sim loj muaj xws li ntshav tsis muaj poov tshuaj thiab mob plawv.Nws zoo nkaus li muaj kev nyab xeeb thaum cev xeeb tub.Muaj ib qho lipid formulation uas muaj kev pheej hmoo ntawm kev phiv.Nws yog nyob rau hauv cov chav kawm polyene ntawm cov tshuaj thiab ua hauj lwm nyob rau hauv ib feem los ntawm kev cuam tshuam cov cell membrane ntawm fungus.Nws yuav tsum tau ceev faj siv thaum muaj xwm txheej tshwm sim, kev siv kev nyab xeeb yuav tsum ua raws li cov lus qhia los ntawm cov neeg ua haujlwm kho mob.
Specification Qhov ncauj Qib (hauv tsev Standard)
| Yam khoom | Specification |
| Qhov tshwm sim | Daj rau txiv kab ntxwv-daj hmoov, tsis muaj ntxhiab los yog yuav luag tsis muaj ntxhiab. |
| Kev txheeb xyuas | IR, HPLC |
| pH | 4.0-6.0 |
| Poob rau ziab | ≤ 5.0% |
| Sulfated tshauv | ≤ 3.0% |
| Yam khoom muaj feem | ≤ 0.5% |
| 303nm ua | Impurity A (Amphotericin A) ≤5.0% Tus neeg tsis paub impurity ≤1.0% |
| 383nm ua | Impurity B (Amphotericin X1) ≤4.0% Tus neeg tsis paub impurity ≤2.0% |
| Tag nrho cov impurities | ≤ 15.0% |
| Cov kuab tshuaj residual | Methanol ≤0.3% Acetone ≤0.5% |
| Assay | ≥850 amphotericin B units / mg rau cov khoom qhuav. |
Specification Qhov ncauj Qib (hauv tsev Standard)
| Yam khoom | Specification |
| Qhov tshwm sim | Yellow rau txiv kab ntxwv hmoov tsis muaj ntxhiab. |
| Kev txheeb xyuas | IR, HPLC |
| Residue ntawm ignition | ≤ 0.5% |
| Cov khoom muaj feem xyuam |
|
| ua 303nm | Amphotericin A ≤ 2.0% |
| Tus neeg tsis paub impurity ≤1.0% | |
| ua 383nm | Amphotericin X1 ≤ 4.0% |
| Tus neeg tsis paub impurity ≤2.0% | |
| Tag nrho impurities | ≤ 15.0% |
| Cov kuab tshuaj residual | Acetone ≤0.5% |
| Methanol ≤0.3% | |
| Microbiological txwv | Aerobic microbial suav ≤1000cfu / g |
| Pwm & poov xab ≤100cfu / g | |
| Escherichia coli tsis muaj nyob hauv 1 g | |
| Cov kab mob endotoxins | <1.0EU/mg |
| Assay | ≥850 amphotericin B units / mg, suav ntawm lub hauv paus qhuav |
