Orlistat 96829-58-2 Antiobesity noj tshuaj ntxiv
Kev Them Nyiaj:T / T, L / C
Khoom Keeb Kwm:Tuam Tshoj
Shipping Chaw nres nkoj:Beijing / Shanghai / Hangzhou
Muaj peev xwm ntau lawm:800kg / hli
Order (MOQ):25kg ua
Lub Sijhawm Lead:3 Hnub Ua Haujlwm
Kev cia khoom:Khaws rau hauv qhov chaw txias, qhuav, chav sov.
Cov khoom siv pob:nruas
Pob loj:25kg / nruas
Cov ntaub ntawv kev nyab xeeb:Tsis yog khoom txaus ntshai
Taw qhia
Orlistat yog qhov ua haujlwm ntev thiab muaj zog tshwj xeeb hauv plab hnyuv lipase inhibitor.Nws yog dawb los yog ze li ntawm hmoov dawb nyob rau hauv chav tsev kub, uas insoluble nyob rau hauv dej, soluble nyob rau hauv chloroform, thiab yooj yim soluble nyob rau hauv ethanol.Nws inactivates lub enzyme los ntawm kev tsim covalent bonds nrog lub active serine chaw ntawm gastric lipase thiab pancreatic lipase nyob rau hauv lub plab thiab cov hnyuv.
Orlistat yog ib hom lipase inhibitor yuag poob tshuaj.Nws yog hydrated derivative ntawm lipstatin, uas tuaj yeem txo qhov nqus ntawm cov zaub mov muaj roj thiab txo qhov hnyav.Cov khoom no muaj zog thiab xaiv inhibition ntawm gastric lipase thiab pancreatic lipase, tsis muaj kev cuam tshuam rau lwm yam digestive enzymes (amylase, trypsin, chymotrypsin) thiab phospholipase, thiab tsis cuam tshuam rau kev nqus ntawm carbohydrates, proteins thiab phospholipids.Nws inactivates lub enzyme tsuas yog los ntawm covalent khi nrog serine residues ntawm lub active chaw ntawm gastric lipase thiab pancreatic lipase nyob rau hauv lub plab hnyuv ib ntsuj av, inhibits lub hydrolysis ntawm triacylglycerol, txo cov kev noj ntawm monoglyceride thiab dawb fatty acid, thiab yog li tswj lub cev hnyav.Cov tshuaj tsis nqus los ntawm txoj hnyuv, thiab inhibition ntawm lipase yog thim rov qab.
Cov khoom no kuj muaj kev ua haujlwm ntawm kev tswj cov ntshav lipids.Nws tuaj yeem txo qis triglyceride thiab qis lipoprotein cholesterol nyob rau hauv cov ntshav ntawm cov neeg mob rog rog thiab nce qhov sib piv ntawm cov lipoprotein ntau ntom ntom rau cov lipoprotein tsawg.
Thaum orlistat ua ke nrog cov khoom noj muaj calorie tsawg, nws yog qhov tsim nyog rau kev kho mob ntev ntawm cov neeg rog thiab rog, suav nrog cov neeg uas tau tsim kev rog muaj feem cuam tshuam.Nws muaj lub sij hawm ntev tswj qhov hnyav xws li poob phaus, kho qhov hnyav thiab tiv thaiv rov qab.Cov kws kho mob qhia pom tseeb tias kev tswj qhov hnyav yog qhov tseem ceeb heev rau kev siv lub sijhawm ntev thaum lub tuam txhab nrog noj mov lossis tom qab ib teev ntawm pluas noj.
Orlistat tuaj yeem txo qis qhov tshwm sim ntawm kev rog rog thiab lwm yam kev rog rog, suav nrog hypercholesterolemia, ntshav qab zib hom II, tsis muaj qabzib siab ntev, hyperinsulinemia, kub siab, thiab txo cov roj cov ntsiab lus hauv nruab nrog cev.
Specification (USP42)
| Yam khoom | Specification |
| Kev txheeb xyuas | HPLC, IR |
| Kev sib hloov kho qhov muag tshwj xeeb | -48.0° ~ 51.0° |
| Cov ntsiab lus dej | ≤ 0.2% |
| Cov khoom muaj feem xyuam I | Orlistat muaj feem xyuam nrog A ≤0.2% |
| Lwm yam khoom II | Orlistat muaj feem cuam tshuam B ≤0.05% |
| Yam khoom III
| Formylleucine ≤0.2% |
| Orlistat muaj feem cuam tshuam C ≤0.05% | |
| Orlistat qhib lub nplhaib epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Tus neeg tsis paub meej impurity ≤0.1% | |
| Yam khoom IV | Orlistat muaj feem cuam tshuam D ≤0.2% |
| Orlistat qhib nplhaib amide ≤0.1% | |
| Cov khoom muaj feem xyuam V | Orlistat muaj feem xyuam nrog E ≤0.2% |
| Tag nrho impurities (I txog V) | ≤ 1.0% |
| Cov kuab tshuaj residual | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Residue ntawm ignition | ≤0.1% |
| Heavy hlau li Pb | ≤20ppm |
| Kev ntsuam xyuas los ntawm HPLC | 98.0% ~ 101.5% (ntawm anhydrous, hnyav-dawb hauv paus) |
