Tulathromycin 217500-96-4 Tshuaj tua kab mob tua kab mob
Kev Them Nyiaj:T / T, L / C
Khoom Keeb Kwm:Tuam Tshoj
Shipping Chaw nres nkoj:Beijing / Shanghai / Hangzhou
Muaj peev xwm ntau lawm:400kg / hli
Order (MOQ):25kg ua
Lub Sijhawm Lead:3 Hnub Ua Haujlwm
Kev cia khoom:Khaws rau hauv qhov chaw txias, qhuav, chav sov.
Cov khoom siv pob:nruas
Pob loj:25kg / nruas
Cov ntaub ntawv kev nyab xeeb:Tsis yog khoom txaus ntshai
Taw qhia
Tulathromycin, yog ib tug dav-spectrum antibacterial neeg sawv cev nrog antibacterial kev ua si tawm tsam ib co gram-positive thiab Gram-negative kab mob.Nws tshwj xeeb tshaj yog rau cov kab mob ntawm cov kab mob ua pa hauv nyuj thiab npua, xws li Actinobacillus pleuropneumoniae, Pasteurella haemolyticus, Pasteurella haemorrhagica, histophilus pw (Haemophilus pw), Mycoplasma pneumoniae, Haemophilus parasuis, Bordetella bronchis, thiab lwm yam.
Cov yam ntxwv pharmacokinetic ntawm Tulathromycin yog tias tom qab kev tswj hwm ib zaug, nws tau nrawm nrawm ntawm qhov chaw txhaj tshuaj, cov ntshav siab zoo tau khaws cia rau lub sijhawm ntev, kev tshem tawm qeeb, pom meej qhov ntim loj, bioavailability siab, thiab qhov concentration ntawm peripheral cov ntaub so ntswg yog siab dua li nyob rau hauv plasma.Cov ntaub so ntswg nthuav dav thiab zoo cell permeability yog cov yam ntxwv tseem ceeb ntawm Tulathromycin metabolism.Tulathromycin yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv kab mob.
Tulathromycin inhibits cov kab mob protein synthesis los ntawm kev thaiv cov kab mob peptide hloov cov txheej txheem.Vim muaj qee qhov tsis xws luag ntawm erythromycin, tib neeg xav tau lwm yam tshuaj los hloov erythromycin sai.Tulathromycin yog ib yam tshiab ntawm macrolide semi hluavtaws tshuaj tua kab mob rau tsiaj.Nws muaj ntau yam zoo, xws li kev siv tshuaj tsawg, kev tswj hwm ib zaug, tsis tshua muaj residue, tsiaj tshwj xeeb thiab lwm yam.Nws tsis tsuas yog muaj qhov zoo ntawm cov tshuaj macrolide, tab sis kuj muaj qhov ntev ib nrab-lub neej uas zoo dua rau lwm cov tshuaj tua kab mob macrolide.Raws li qhov ua tau zoo ntawm kev tswj cov kev kho mob zoo hauv lub cev rau lub sijhawm ntev, nws tuaj yeem ua tiav cov kab mob bacteriostasis zoo dua thiab ua kom tsis muaj menyuam.
Tom qab daim ntawv thov kev kho mob dav dav, tulathromycin muaj cov txiaj ntsig kho mob rau cov kab mob ua pa ntawm nyuj thiab npua.Ua tsaug rau cov tshuaj tua kab mob zoo heev ntawm Tulathromycin zoo li kev siv me me, ntev ib nrab-lub neej thiab kev tswj hwm ib zaug, nws tuaj yeem siv dav.
Tulathromycin muaj zog dua li cov macrolides dav siv hauv kev ua lag luam tam sim no, xws li tylosin, tilmicosin thiab florfenicol.Uas muaj peev xwm loj heev thov.
Nco ntsoov them nyiaj tias Tulathromycin muaj kev nyab xeeb, tsis muaj carcinogenicity, teratogenicity thiab genotoxicity.Nws yuav tsis ua rau cov noob hloov pauv, tab sis tuaj yeem ua rau cardiotoxicity.Yuav tsum tau ua raws li cov lus qhia ntawm kws kho tsiaj.
Specification (hauv tsev Standard)
| Yam khoom | Specification |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov |
| Solubility | Nws yog dawb do soluble hauv methanol, acetone, thiab methyl acetate, soluble hauv ethanol |
| Kev sib hloov kho qhov muag tshwj xeeb | -22 ° rau -26 ° |
| Kev txheeb xyuas | HPLC: Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm kev tshuaj ntsuam kev npaj sib raug rau qhov hauv chromatogram ntawm kev npaj strandard tau txais raws li tau teev tseg hauv qhov kev xeem IR: IR spectrum zoo ib yam nrog CRS |
| Dej | ≤ 2.5% |
| Residue ntawm ignition | ≤0.10% |
| Cov hlau hnyav | ≤20ppm |
| Muaj feem xyuam | Tag nrho impurity ≤6.0% Tus kheej impurity ≤3.0% |
| Cov kab mob endotoxin | <2 EU |
| Assay (anhydrous tshuaj) | 95% -103% |
| Residual kuab tshuaj | N-Heptane ≤5000ppm Dichloromethane ≤600ppm |
| Assay | Cov ntsiab lus ntawm C41H79N3O12: 95% -103% (Ntawm yam khoom siv) |
