Tacrolimus monohydrate 109581-93-3 Tshuaj tua kab mob
Kev Them Nyiaj:T / T, L / C
Khoom Keeb Kwm:Tuam Tshoj
Shipping Chaw nres nkoj:Beijing / Shanghai / Hangzhou
Muaj peev xwm ntau lawm:1 kg / hli
Order (MOQ):1g ua
Lub Sijhawm Lead:3 Hnub Ua Haujlwm
Kev cia khoom:Khaws rau hauv qhov chaw txias, qhuav, chav sov.
Cov khoom siv pob:vial, ua
Pob loj:1g / vial, 5 / vial, 10g / vial, 50g / lub raj mis, 500g / lub raj mis
Cov ntaub ntawv kev nyab xeeb:UN 2811 6.1/PG 3
Taw qhia
Tacrolimus, yog ib qho tshuaj tiv thaiv kab mob.Tom qab kev hloov pauv hauv lub cev allogeneic, qhov kev pheej hmoo ntawm kev tsis lees paub lub cev yog nruab nrab.Txhawm rau txo qhov kev pheej hmoo ntawm lub cev tsis lees paub, tacrolimus tau muab.Cov tshuaj kuj tuaj yeem raug muag raws li cov tshuaj pleev ib ce hauv kev kho mob ntawm T-cell-mediated kab mob xws li eczema thiab psoriasis.Nws tuaj yeem siv los kho qhov muag qhuav syndrome hauv miv thiab dev.
Tacrolimus inhibits calcineurin, uas koom nrog hauv kev tsim cov interleukin-2, ib qho molecule uas txhawb txoj kev loj hlob thiab kev loj hlob ntawm T hlwb, raws li ib feem ntawm lub cev kawm (los yog adaptive) tiv thaiv kab mob.
Specification (USP43)
| Yam khoom | Specification |
| Qhov tshwm sim | Dawb los yog yuav luag dawb crystalline hmoov |
| Kev txheeb xyuas | IR, HPLC |
| Solubility | Soluble heev nyob rau hauv methanol, dawb soluble nyob rau hauv N, N dimethylformamide thiab cawv, xyaum nyob rau hauv soluble nyob rau hauv dej. |
| Residue ntawm ignition | ≤0.10% |
| Organic impurities ( txheej txheem-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50% | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-propyl analog ≤0.15% | |
| Tsis paub impurity -I ≤0.10% | |
| Tsis paub impurity -II ≤0.10% | |
| Tsis paub impurity -III ≤0.10% | |
| Tag nrho impurities ≤1.00% | |
| Optical rotation (raws li lub hauv paus) (10mg / ml hauv N, Ndimethylformamide) | -110.0° ~ -115.0° |
| Cov ntsiab lus dej (los ntawm KF) | ≤ 4.0% |
| Residual solvents (los ntawm GC) | Acetone ≤1000ppm (hauv tsev) |
| Di-isopropyl ether ≤100ppm (hauv tsev) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Microbial Test (hauv tsev) | Tag nrho aerobic microbial suav ≤100cfu / gm |
| Tag nrho cov poov xab thiab pwm suav ≤10cfu / gm | |
| Cov kab mob tshwj xeeb (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) yuav tsum tsis tuaj | |
| Assay (los ntawm HPLC) (raws li anhydrous thiab hnyav hnyav) | 98% ~ 102% |
